Reactome | CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments

CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments

Stable Identifier

R-HSA-5244669

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments

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Phosphorylation of the N-termini of lamins by CDK1 (serine S23 of lamin B, serin S22 of lamin A and C) probably happens consequentially with phosphorylation of C-termini of lamins by PKC, and contributes to the depolymerization of lamin filaments and solubilization of the nuclear lamina (Ward and Kirschner 1990, Peter et al. 1990, Heald and McKeon 1990, Mall et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22986494	Mitotic lamin disassembly is triggered by lipid-mediated signaling Mall, M, Walter, T, Gorjánácz, M, Davidson, IF, Nga Ly-Hartig, TB, Ellenberg, J, Mattaj, IW	J. Cell Biol.	2012
2344612	Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis Heald, R, McKeon, F	Cell	1990
2188731	In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase Peter, M, Nakagawa, J, Dorée, M, Labbé, JC, Nigg, EA	Cell	1990
2188730	Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C Ward, GE, Kirschner, MW	Cell	1990