Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes

Stable Identifier
R-HSA-170070
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

WEE1, a nuclear kinase, phosphorylates cyclin B1:Cdc2 (CCNB1:CDK1) on tyrosine 15 (Y15), inactivating the complex (Parker and Piwnica-Worms 1992, McGowan and Russell 1993). The complex of cyclin B2 and Cdc2 (CCNB2:CDK1) is also phosphorylated on Y15 (Galaktionov and Beach 1991).

Literature References
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of WEE1 [nucleoplasm]
Physical Entity
WEE1 [nucleoplasm]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes (Homo sapiens)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Bos taurus)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Caenorhabditis elegans)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Canis familiaris)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Danio rerio)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Drosophila melanogaster)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Mus musculus)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Rattus norvegicus)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Sus scrofa)
Created
Matthews, L  (2005-12-23)