Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes

Stable Identifier
R-HSA-170070
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes
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WEE1, a nuclear kinase, phosphorylates cyclin B1:Cdc2 (CCNB1:CDK1) on tyrosine 15 (Y15), inactivating the complex (Parker and Piwnica-Worms 1992, McGowan and Russell 1993). The complex of cyclin B2 and Cdc2 (CCNB2:CDK1) is also phosphorylated on Y15 (Galaktionov and Beach 1991).

Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of WEE1 [nucleoplasm]

Physical Entity
WEE1 [nucleoplasm] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes (Homo sapiens)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Bos taurus)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Canis familiaris)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Danio rerio)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Drosophila melanogaster)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Mus musculus)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Rattus norvegicus)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Sus scrofa)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Xenopus tropicalis)
Created
Matthews, L  (2005-12-23)
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