WEE1, a nuclear kinase, phosphorylates cyclin B1:Cdc2 (CCNB1:CDK1) on tyrosine 15 (Y15), inactivating the complex (Parker and Piwnica-Worms 1992, McGowan and Russell 1993). The complex of cyclin B2 and Cdc2 (CCNB2:CDK1) is also phosphorylated on Y15 (Galaktionov and Beach 1991).
Galaktionov, K, Beach, D
Piwnica-Worms, H, Parker, LL
McGowan, CH, Russell, P
protein tyrosine kinase activity of WEE1 [nucleoplasm]
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