CHEK1 phosphorylates TP53

Stable Identifier
R-HSA-6799246
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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CHEK1 phosphorylates TP53
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CHEK1, activated by ATR-mediated phosphorylation, can phosphorylate TP53 at serine residue S20, resulting in the increased half-life of TP53 (Shieh et al. 2000).

Literature References
PubMed ID Title Journal Year
10673501 The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

Shieh, SY, Ahn, J, Tamai, K, Taya, Y, Prives, C

Genes Dev 2000
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S317,S345-CHEK1 [nucleoplasm]
Physical Entity
p-S317,S345-CHEK1 [nucleoplasm]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
CHEK1 phosphorylates TP53 (Bos taurus)
CHEK1 phosphorylates TP53 (Danio rerio)
CHEK1 phosphorylates TP53 (Drosophila melanogaster)
CHEK1 phosphorylates TP53 (Mus musculus)
CHEK1 phosphorylates TP53 (Rattus norvegicus)
CHEK1 phosphorylates TP53 (Sus scrofa)
CHEK1 phosphorylates TP53 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-22)