Reactome | CHEK1 phosphorylates TP53

CHEK1 phosphorylates TP53

Stable Identifier

R-HSA-6799246

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        CHEK1 phosphorylates TP53 (Homo sapiens)

General

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SVG | | PPTX | SBGN

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CHEK1, activated by ATR-mediated phosphorylation, can phosphorylate TP53 at serine residue S20, resulting in the increased half-life of TP53 (Shieh et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10673501	The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Shieh, SY, Ahn, J, Tamai, K, Taya, Y, Prives, C	Genes Dev	2000