CHEK1 phosphorylates TP53

Stable Identifier
R-HSA-6799246
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CHEK1 phosphorylates TP53
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
CHEK1, activated by ATR-mediated phosphorylation, can phosphorylate TP53 at serine residue S20, resulting in the increased half-life of TP53 (Shieh et al. 2000).
Literature References
PubMed ID Title Journal Year
10673501 The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

Shieh, SY, Ahn, J, Tamai, K, Taya, Y, Prives, C

Genes Dev 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-S317,S345-CHEK1 [nucleoplasm]

Physical Entity
p-S317,S345-CHEK1 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
CHEK1 phosphorylates TP53 (Canis familiaris)
CHEK1 phosphorylates TP53 (Drosophila melanogaster)
CHEK1 phosphorylates TP53 (Mus musculus)
CHEK1 phosphorylates TP53 (Rattus norvegicus)
CHEK1 phosphorylates TP53 (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-22)
Cite Us!