CHEK1 phosphorylates TP53

Stable Identifier
R-HSA-6799246
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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CHEK1 phosphorylates TP53
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CHEK1, activated by ATR-mediated phosphorylation, can phosphorylate TP53 at serine residue S20, resulting in the increased half-life of TP53 (Shieh et al. 2000).

Literature References
PubMed ID Title Journal Year
10673501 The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

Tamai, K, Taya, Y, Ahn, J, Prives, C, Shieh, SY

Genes Dev 2000
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-S317,S345-CHEK1 [nucleoplasm]

Physical Entity
p-S317,S345-CHEK1 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
CHEK1 phosphorylates TP53 (Canis familiaris)
CHEK1 phosphorylates TP53 (Danio rerio)
CHEK1 phosphorylates TP53 (Drosophila melanogaster)
CHEK1 phosphorylates TP53 (Mus musculus)
CHEK1 phosphorylates TP53 (Rattus norvegicus)
CHEK1 phosphorylates TP53 (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Inga, A  (2016-02-04)
Zaccara, S  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-22)
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