Reactome | Activated JNKs phosphorylate c-JUN

Activated JNKs phosphorylate c-JUN

Stable Identifier

R-HSA-168136

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-17 signaling (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        Activated JNKs phosphorylate c-JUN (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Fc epsilon receptor (FCERI) signaling (Homo sapiens)
    - FCERI mediated MAPK activation (Homo sapiens)
      - Activated JNKs phosphorylate c-JUN (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        Activated JNKs phosphorylate c-JUN (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        Activated JNKs phosphorylate c-JUN (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        Activated JNKs phosphorylate c-JUN (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        Activated JNKs phosphorylate c-JUN (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        Activated JNKs phosphorylate c-JUN (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        Activated JNKs phosphorylate c-JUN (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        Activated JNKs phosphorylate c-JUN (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        Activated JNKs phosphorylate c-JUN (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        Activation of the AP-1 family of transcription factors (Homo sapiens)
        
        Activated JNKs phosphorylate c-JUN (Homo sapiens)

General

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JNK (c-Jun N-terminal Kinase) phosphorylates several transcription factors including c-Jun after translocation to the nucleus.

Literature References

PubMed ID	Title	Journal	Year
18793328	c-Jun expression, activation and function in neural cell death, inflammation and repair Raivich, G	J Neurochem	2008
10871633	c-Jun inhibits transforming growth factor beta-mediated transcription by repressing Smad3 transcriptional activity Ferrand, N, Prunier, C, Atfi, A, Gauthier, JM, Dennler, S	J Biol Chem	2000