p38MAPK phosphorylates MSK1

Stable Identifier
R-HSA-198669
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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p38MAPK phosphorylates MSK1
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MSK1 (Ribosomal protein S6 kinase alpha-5) is a serine/threonine kinase that is localised in the nucleus. It contains two protein kinase domains in a single polypeptide. It can be activated 5-fold by p38MAPK through phosphorylation at four key residues.
Literature References
PubMed ID Title Journal Year
9687510 Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

Deak, M, Clifton, AD, Lucocq, LM, Alessi, DR

EMBO J 1998
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-p38 MAPK alpha/beta [nucleoplasm]

Physical Entity
p-p38 MAPK alpha/beta [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
p38MAPK phosphorylates MSK1 (Bos taurus)
p38MAPK phosphorylates MSK1 (Caenorhabditis elegans)
p38MAPK phosphorylates MSK1 (Canis familiaris)
p38MAPK phosphorylates MSK1 (Danio rerio)
p38MAPK phosphorylates MSK1 (Dictyostelium discoideum)
p38MAPK phosphorylates MSK1 (Drosophila melanogaster)
p38MAPK phosphorylates MSK1 (Gallus gallus)
p38MAPK phosphorylates MSK1 (Mus musculus)
p38MAPK phosphorylates MSK1 (Rattus norvegicus)
p38MAPK phosphorylates MSK1 (Saccharomyces cerevisiae)
p38MAPK phosphorylates MSK1 (Schizosaccharomyces pombe)
p38MAPK phosphorylates MSK1 (Sus scrofa)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
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