Human MDM4 (MDMX) is phosphorylated on serine residue S403 by ATM. This site is important for MDM2-mediated ubiquitination of MDM4 after induction of double strand DNA breaks (Pereg et al. 2005, Chen et al. 2005).
Pereg, Y, Shkedy, D, de Graaf, P, Meulmeester, E, Edelson-Averbukh, M, Salek, M, Biton, S, Teunisse, AF, Lehmann, WD, Jochemsen, AG, Shiloh, Y
Chen, L, Gilkes, DM, Pan, Y, Lane, WS, Chen, J
© 2021 Reactome