Reactome | Phosphorylation of MDM4 by ATM

Phosphorylation of MDM4 by ATM

Stable Identifier

R-HSA-349455

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
      - p53-Dependent G1 DNA Damage Response (Homo sapiens)
        
        Stabilization of p53 (Homo sapiens)
        
        Phosphorylation of MDM4 by ATM (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        Phosphorylation of MDM4 by ATM (Homo sapiens)

General

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Human MDM4 (MDMX) is phosphorylated on serine residue S403 by ATM. This site is important for MDM2-mediated ubiquitination of MDM4 after induction of double strand DNA breaks (Pereg et al. 2005, Chen et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
16163388	ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage Chen, L, Gilkes, DM, Pan, Y, Lane, WS, Chen, J	EMBO J	2005
15788536	Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage Pereg, Y, Shkedy, D, de Graaf, P, Meulmeester, E, Edelson-Averbukh, M, Salek, M, Biton, S, Teunisse, AF, Lehmann, WD, Jochemsen, AG, Shiloh, Y	Proc Natl Acad Sci U S A	2005