Phosphorylation of MDM4 by ATM

Stable Identifier
R-HSA-349455
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Human MDM4 (MDMX) is phosphorylated on serine residue S403 by ATM. This site is important for MDM2-mediated ubiquitination of MDM4 after induction of double strand DNA breaks (Pereg et al. 2005, Chen et al. 2005).

Literature References
PubMed ID Title Journal Year
16163388 ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

Lane, WS, Chen, L, Pan, Y, Chen, J, Gilkes, DM

EMBO J 2005
15788536 Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

Shiloh, Y, Meulmeester, E, Jochemsen, AG, Pereg, Y, Teunisse, AF, Shkedy, D, de Graaf, P, Biton, S, Lehmann, WD, Edelson-Averbukh, M, Salek, M

Proc Natl Acad Sci U S A 2005
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
Cite Us!