Reactome | Phosphorylation of MDM4 by ATM

Phosphorylation of MDM4 by ATM

Stable Identifier

R-HSA-349455

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
      - p53-Dependent G1 DNA Damage Response (Homo sapiens)
        
        Stabilization of p53 (Homo sapiens)
        
        Phosphorylation of MDM4 by ATM (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        Phosphorylation of MDM4 by ATM (Homo sapiens)

General

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SVG | | PPTX | SBGN

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Human MDM4 (MDMX) is phosphorylated on serine residue S403 by ATM. This site is important for MDM2-mediated ubiquitination of MDM4 after induction of double strand DNA breaks (Pereg et al. 2005, Chen et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15788536	Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage Pereg, Y, Shkedy, D, de Graaf, P, Meulmeester, E, Edelson-Averbukh, M, Salek, M, Biton, S, Teunisse, AF, Lehmann, WD, Jochemsen, AG, Shiloh, Y	Proc Natl Acad Sci U S A	2005
16163388	ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage Chen, L, Gilkes, DM, Pan, Y, Lane, WS, Chen, J	EMBO J	2005