AKT1 E17K mutant phosphorylates forkhead box transcription factors

Stable Identifier
R-HSA-2399992
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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AKT1 E17K mutant phosphorylates forkhead box transcription factors
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AKT1 E17K gain-of-function mutant phosphorylates FOXO3 (Carpten et al. 2007), and is expected to phosphorylate other forkhead box transcription factor family members, FOXO1 and FOXO4, and possibly FOXO6, like the wild-type AKT (Brunet et al. 1999, Rena et al. 1999, Matsuzaki et al. 2005), but this has not been experimentally tested.
Literature References
PubMed ID Title Journal Year
10102273 Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Hu, LS, Bonni, A, Brunet, A, Blenis, J, Zigmond, MJ, Anderson, MJ, Lin, MZ, Greenberg, ME, Juo, P, Arden, KC

Cell 1999
10358075 Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

Unterman, TG, Guo, S, Cichy, SC, Rena, G, Cohen, P

J Biol Chem 1999
17611497 A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

Tucker-Kellogg, G, Lin, A, Blanchard, KL, Carpten, JD, Qian, YW, Moses, TY, Briggs, SL, Zeckner, DJ, Hostetter, G, Bittner, M, Savage, S, Thomas, JE, Uhlik, M, Du, J, Boguslawski, S, Robbins, CM, Schevitz, R, Touchman, J, Patel, K, Mousses, S, Lai, MHT, Faber, AL, Donoho, GP, Horn, C

Nature 2007
16272144 Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved among the FOXO family

Kikkawa, U, Yamamoto, T, Hayashi, T, Ichino, A, Matsuzaki, H

J Biochem (Tokyo) 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [nucleoplasm]

Physical Entity
p-T308,S473-AKT1 E17K [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Normal reaction
AKT phosphorylates FOXO transcription factors (Homo sapiens)
Functional status

Gain of function of p-T308,S473-AKT1 E17K [nucleoplasm]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2012-07-18)
Reviewed
Zhao, JJ  (2012-08-13)
Yuzugullu, H  (2012-08-13)
Thorpe, L  (2012-08-13)
Created
Orlic-Milacic, M  (2012-07-13)
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