AKT1 E17K mutant phosphorylates forkhead box transcription factors

Stable Identifier
R-HSA-2399992
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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AKT1 E17K gain-of-function mutant phosphorylates FOXO3 (Carpten et al. 2007), and is expected to phosphorylate other forkhead box transcription factor family members, FOXO1 and FOXO4, and possibly FOXO6, like the wild-type AKT (Brunet et al. 1999, Rena et al. 1999, Matsuzaki et al. 2005), but this has not been experimentally tested.

Literature References
PubMed ID Title Journal Year
10358075 Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

Rena, G, Guo, S, Cichy, SC, Unterman, TG, Cohen, P

J Biol Chem 1999
10102273 Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Brunet, A, Bonni, A, Zigmond, MJ, Lin, MZ, Juo, P, Hu, LS, Anderson, MJ, Arden, KC, Blenis, J, Greenberg, ME

Cell 1999
17611497 A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

Carpten, JD, Faber, AL, Horn, C, Donoho, GP, Briggs, SL, Robbins, CM, Hostetter, G, Boguslawski, S, Moses, TY, Savage, S, Uhlik, M, Lin, A, Du, J, Qian, YW, Zeckner, DJ, Tucker-Kellogg, G, Touchman, J, Patel, K, Mousses, S, Bittner, M, Schevitz, R, Lai, MHT, Blanchard, KL, Thomas, JE

Nature 2007
16272144 Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved among the FOXO family

Matsuzaki, H, Ichino, A, Hayashi, T, Yamamoto, T, Kikkawa, U

J Biochem (Tokyo) 2005
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [nucleoplasm]

Normal reaction
Functional status

Gain of function of p-T308,S473-AKT1 E17K [nucleoplasm]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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