LKB1 phosphorylates the alpha subunit of AMPK heterotrimer

Stable Identifier
R-HSA-164151
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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LKB1 phosphorylates threonine residue 172 of the alpha subunit of the AMPK heterotrimer, activating it. LKB1, a serine/threonine kinase, was first identified as the gene whose mutation is associated with the Peutz-Jeghers familial cancer syndrome. This disease phenotype is consistent with the hypothesis that the interaction between LKB1 and AMPK normally plays a key role in the negative regulation of cell growth (Hardie 2004).

Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of STK11 [nucleoplasm]

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