SRPK1 phosphorylates PRM2 in PRM2:dsDNA

Stable Identifier
R-HSA-9821967
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SRPK1 phosphorylates PRM2 in PRM2:dsDNA
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In the male pronucleus of the zygote, Serine-arginine-rich protein kinase 1 (SRPK1) phosphorylates PRM2 on serine-8 and serine-10. This reaction is inferred from the mouse homologs in which Srpk1 phosphorylates Prm2 on serine-8, serine-10, serine-56, and serine-69. Human PRM2, however, does not have serine residues corresponding to serine-56 and serine-69 of mouse Prm2.
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Output
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Catalyst Activity

protein serine kinase activity of SRPK1:Mg2+ [nucleoplasm]

Physical Entity
SRPK1:Mg2+ [nucleoplasm] (Homo sapiens)
Activity
protein serine kinase activity (GO:0106310)
Inferred From
Srpk1 phosphorylates Prm2 in Prm2:dsDNA (Mus musculus)
Authored
May, B  (2022-12-12)
Reviewed
Xie, W  (2023-08-08)
Created
May, B  (2022-12-16)
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