PRKCI phosphorylates ELF3

Stable Identifier
R-HSA-9021357
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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PRKCI phosphorylates ELF3
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PRKCI (protein kinase C iota), activated in response to KRAS signaling, phosphorylates transcription factor ELF3 on serine residue S68. PRKCI-mediated phosphorylation of ELF3 promotes transcriptional activity of ELF3, probably by stimulating nuclear retention or import of ELF3 (Ali et al. 2016).

Literature References
PubMed ID Title Journal Year
26977885 Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma

Ali, SA, Justilien, V, Jamieson, L, Murray, NR, Fields, AP

Cancer Cell 2016
Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
positive regulation of Notch signaling pathway (0045747)
Catalyst Activity
Catalyst Activity
Title
protein kinase C activity of PRKCI [nucleoplasm]
Physical Entity
PRKCI [nucleoplasm]
Activity
protein kinase C activity (0004697)
Orthologous Events
PRKCI phosphorylates ELF3 (Bos taurus)
PRKCI phosphorylates ELF3 (Caenorhabditis elegans)
PRKCI phosphorylates ELF3 (Canis familiaris)
PRKCI phosphorylates ELF3 (Danio rerio)
PRKCI phosphorylates ELF3 (Gallus gallus)
PRKCI phosphorylates ELF3 (Mus musculus)
PRKCI phosphorylates ELF3 (Rattus norvegicus)
PRKCI phosphorylates ELF3 (Sus scrofa)
PRKCI phosphorylates ELF3 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Orlic-Milacic, M  (2017-09-18)
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