PRKCI phosphorylates ELF3

Stable Identifier
R-HSA-9021357
Type
Reaction
Species
Homo sapiens
Compartment
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PRKCI (protein kinase C iota), activated in response to KRAS signaling, phosphorylates transcription factor ELF3 on serine residue S68. PRKCI-mediated phosphorylation of ELF3 promotes transcriptional activity of ELF3, probably by stimulating nuclear retention or import of ELF3 (Ali et al. 2016).

Literature References
PubMed ID Title Journal Year
26977885 Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma

Jamieson, L, Justilien, V, Murray, NR, Ali, SA, Fields, AP

Cancer Cell 2016
Participants
Participates
Event Information
Catalyst Activity

protein kinase C activity of PRKCI [nucleoplasm]

Orthologous Events
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