PRKCI phosphorylates ELF3

Stable Identifier
R-HSA-9021357
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PRKCI phosphorylates ELF3
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PRKCI (protein kinase C iota), activated in response to KRAS signaling, phosphorylates transcription factor ELF3 on serine residue S68. PRKCI-mediated phosphorylation of ELF3 promotes transcriptional activity of ELF3, probably by stimulating nuclear retention or import of ELF3 (Ali et al. 2016).
Literature References
PubMed ID Title Journal Year
26977885 Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma

Jamieson, L, Justilien, V, Murray, NR, Ali, SA, Fields, AP

Cancer Cell 2016
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
positive regulation of Notch signaling pathway (0045747)
Catalyst Activity

diacylglycerol-dependent serine/threonine kinase activity of PRKCI [nucleoplasm]

Physical Entity
PRKCI [nucleoplasm] (Homo sapiens)
Activity
diacylglycerol-dependent serine/threonine kinase activity (GO:0004697)
Orthologous Events
PRKCI phosphorylates ELF3 (Bos taurus)
PRKCI phosphorylates ELF3 (Caenorhabditis elegans)
PRKCI phosphorylates ELF3 (Canis familiaris)
PRKCI phosphorylates ELF3 (Gallus gallus)
PRKCI phosphorylates ELF3 (Mus musculus)
PRKCI phosphorylates ELF3 (Rattus norvegicus)
PRKCI phosphorylates ELF3 (Sus scrofa)
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Orlic-Milacic, M  (2017-09-18)
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