ATM phosphorylates WHSC1

Stable Identifier
R-HSA-5682983
Type
Reaction
Species
Homo sapiens
Compartment
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Activated ATM phosphorylates WHSC1 (MMSET) on serine residue S102 (Matsuoka et al. 2007). The BRCT domain of MDC1 binds phosphorylated WHSC1, which is necessary for retention of WHSC1 at DNA double-strand break (DSB) sites (Pei et al. 2011).

Literature References
PubMed ID Title Journal Year
17525332 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

Gygi, SP, Lerenthal, Y, Hurov, KE, Bakalarski, CE, Shiloh, Y, Smogorzewska, A, Ballif, BA, Zhao, Z, Elledge, SJ, Matsuoka, S, Luo, J, McDonald, ER, Solimini, N

Science 2007
21293379 MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

You, Z, Lou, Z, Chesi, M, Pei, H, Bergsagel, PL, Luo, K, Wang, L, Qin, Y, Zhang, L, Fei, F

Nature 2011
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm]

Orthologous Events
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