ATM phosphorylates WHSC1

Stable Identifier
R-HSA-5682983
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated ATM phosphorylates WHSC1 (MMSET) on serine residue S102 (Matsuoka et al. 2007). The BRCT domain of MDC1 binds phosphorylated WHSC1, which is necessary for retention of WHSC1 at DNA double strand break (DSB) sites (Pei et al. 2011).

Literature References
PubMed ID Title Journal Year
21293379 MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

Pei, H, Zhang, L, Luo, K, Qin, Y, Chesi, M, Fei, F, Bergsagel, PL, Wang, L, You, Z, Lou, Z

Nature 2011
17525332 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

Matsuoka, S, Ballif, BA, Smogorzewska, A, McDonald, ER, Hurov, KE, Luo, J, Bakalarski, CE, Zhao, Z, Solimini, N, Lerenthal, Y, Shiloh, Y, Gygi, SP, Elledge, SJ

Science 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created