Reactome | AK6 phosphorylates (d)NMPs to (d)NDPs

AK6 phosphorylates (d)NMPs to (d)NDPs

Stable Identifier

R-HSA-6788810

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Adenylate kinases (AKs) are nucleoside monophosphate kinases, which catalyze the phosphorylation of AMP by using ATP or GTP as phosphate donors. AKs are thus involved in maintaining the homeostasis of cellular nucleotides. CMP, dCMP and dAMP are other substrates phosphorylated with less efficiency by AKs. When GTP is the phosphate donor, only AMP and CMP are efficiently phosphorylated. Adenylate kinase 6 (AK6) is thought to mediate nucleotide homeostasis in the nucleoplasm (Ren et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15630091	The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus Ren, H, Wang, L, Bennett, M, Liang, Y, Zheng, X, Lu, F, Li, L, Nan, J, Luo, M, Eriksson, S, Zhang, C, Su, XD	Proc. Natl. Acad. Sci. U.S.A.	2005