Aurkb phosphorylates Mecp2 at S421

Stable Identifier
R-MMU-9023138
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Aurkb phosphorylates Mecp2 at S421
Mouse Aurkb (Aurora kinase B) phosphorylates mouse Mecp2 at serine residue S421 in dividing adult neuronal progenitor cells (Li et al. 2014).
Literature References
PubMed ID Title Journal Year
25420914 Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway

Li, H, Zhong, X, Chau, KF, Santistevan, NJ, Guo, W, Kong, G, Li, X, Kadakia, M, Masliah, J, Chi, J, Jin, P, Zhang, J, Zhao, X, Chang, Q

Nat Commun 2014
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of Aurkb [nucleoplasm]

Physical Entity
Aurkb [nucleoplasm] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
AURKB phosphorylates MECP2 at S423 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Christodoulou, J  (2018-08-07)
Krishnaraj, R  (2018-08-07)
Created
Orlic-Milacic, M  (2017-09-27)
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