Phosphorylation of UBF-1:rDNA Promoter

Stable Identifier
R-HSA-73722
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phosphorylation of UBF-1, bound to the promoter, activates UBF-1 and recruits SL1, and eventually polymerase. This phosphorylation of UBF-1 by Erk1, has been shown to both weaken the binding of UBF-1 to DNA and to activate transcription (the authors of the paper showing these data suggest that loosening the binding of UBF-1 with the promoter may somehow promote transcription initiation). Though not definitively worked out phosphorylation of UBF-1 by Erk1 plays a role in the activation of the UBF-1:rDNA complex.

Literature References
PubMed ID Title Journal Year
11741541 An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF.

Stefanovsky, VY, Pelletier, G, Hannan, R, Gagnon-Kugler, T, Rothblum, LI, Moss, T

Mol Cell 2001
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Participant Of
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Catalyst Activity
Title
MAP kinase activity of p-T202, Y204 MAPK3 dimer [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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