Phosphorylation of Cyclin A:Cdk2 at Tyr 15

Stable Identifier
R-HSA-174164
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The CDK activity of the Cyclin A:Cdk2 complex is inhibited by phosphorylation at Tyr-15 by the WEE1 kinase (Gu et al. 1992, Wu et al. 2001). WEE1-mediated phosphorylation of cyclin A-bound CDK2 is positively regulated by CABLES1 (Wu et al. 2001).

Literature References
PubMed ID Title Journal Year
1396589 Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15

Gu, Y, Rosenblatt, J, Morgan, DO

EMBO J 1992
11585773 Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers

Wu, CL, Kirley, SD, Xiao, H, Chuang, Y, Chung, DC, Zukerberg, LR

Cancer Res 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of WEE1 [nucleoplasm]
Physical Entity
Activity
This event is regulated
Positively by
Orthologous Events
Authored
Reviewed
Created