I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus

Stable Identifier
R-HSA-1855206
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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In the nucleus, inositol polyphosphate multikinase (IPMK) phosphorylates inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) to inositol 1,3,4,5,6-pentakisphosphate (I(1,3,4,5,6)P5) (Nalaskowski et al. 2002, Chang & Majerus 2006).
Literature References
PubMed ID Title Journal Year
16293229 Inositol polyphosphate multikinase regulates inositol 1,4,5,6-tetrakisphosphate

Majerus, PW, Chang, SC

Biochem Biophys Res Commun 2006
12027805 The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization

Nalaskowski, MM, Deschermeier, C, Mayr, GW, Fanick, W

Biochem J 2002
Participants
Participates
Catalyst Activity

inositol tetrakisphosphate 6-kinase activity of IPMK [nucleoplasm]

Orthologous Events
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