Phosphorylation of Chk2 by ATM upon DNA damage

Stable Identifier
R-GGA-265959
Type
Reaction [transition]
Species
Gallus gallus
Compartment
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Chk2 phosphorylation by ATM requires NBS1 following DSB formation. A tumor suppressor role for Chk2 has been implicated in inducing a G2 arrest and delaying mitotic exit following irradiation induced damage.

Literature References
PubMed ID Title Journal Year
17684483 Chk2 is required for optimal mitotic delay in response to irradiation-induced DNA damage incurred in G2 phase

Rainey, MD, Black, EJ, Zachos, G, Gillespie, DA

Oncogene 2008
16824197 ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin

Kobayashi, M, Ono, H, Mihara, K, Tauchi, H, Komatsu, K, Shibata, T, Shimizu, H, Uchida, K, Yamamoto, K

Genes Cells 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of ATM [nucleoplasm]
Physical Entity
Activity
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Created