Phosphorylation of Chk2 by ATM upon DNA damage

Stable Identifier
R-GGA-265959
Type
Reaction [transition]
Species
Gallus gallus
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylation of Chk2 by ATM upon DNA damage
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Chk2 phosphorylation by ATM requires NBS1 following DSB formation. A tumor suppressor role for Chk2 has been implicated in inducing a G2 arrest and delaying mitotic exit following irradiation induced damage.
Literature References
PubMed ID Title Journal Year
16824197 ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin

Shimizu, H, Mihara, K, Tauchi, H, Uchida, K, Shibata, T, Ono, H, Yamamoto, K, Komatsu, K, Kobayashi, M

Genes Cells 2006
17684483 Chk2 is required for optimal mitotic delay in response to irradiation-induced DNA damage incurred in G2 phase

Gillespie, DA, Black, EJ, Rainey, MD, Zachos, G

Oncogene 2008
Participants
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Output
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Catalyst Activity

protein serine/threonine kinase activity of ATM [nucleoplasm]

Physical Entity
ATM [nucleoplasm] (Gallus gallus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Saxena, A  (2008-01-04)
Reviewed
Borowiec, JA  (2009-04-24)
Created
Saxena, A  (2008-04-21)
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