AMPK phosphorylates TP53

Stable Identifier
R-HSA-6805470
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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AMPK phosphorylates TP53
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AMPK, activated in response to glucose deprivation, phosphorylates TP53 (p53) on serine residue S15, initiating AMPK-dependent cell cycle arrest (Jones et al. 2005). AMPK-dependent phosphorylation of TP73 (p73) appears to be involved in TP53 stabilization upon AMPK activation (Adamovich et al. 2014).
Literature References
PubMed ID Title Journal Year
24874608 AMPK couples p73 with p53 in cell fate decision

Adamovich, Y, Adler, J, Meltser, V, Reuven, N, Shaul, Y

Cell Death Differ. 2014
15866171 AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

Jones, RG, Plas, DR, Kubek, S, Buzzai, M, Mu, J, Xu, Y, Birnbaum, MJ, Thompson, CB

Mol. Cell 2005
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Catalyst Activity

AMP-activated protein kinase activity of Activated AMPK heterotrimer [nucleoplasm]

Physical Entity
Activated AMPK heterotrimer [nucleoplasm] (Homo sapiens)
Activity
AMP-activated protein kinase activity (GO:0004679)
Orthologous Events
AMPK phosphorylates TP53 (Bos taurus)
AMPK phosphorylates TP53 (Canis familiaris)
AMPK phosphorylates TP53 (Danio rerio)
AMPK phosphorylates TP53 (Drosophila melanogaster)
AMPK phosphorylates TP53 (Mus musculus)
AMPK phosphorylates TP53 (Rattus norvegicus)
AMPK phosphorylates TP53 (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-19)
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