Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)

Stable Identifier
R-HSA-442724
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CREB1 is phosphorylated at serine residue S133 by any of the three isoforms of ribosomal S6 kinase (RSK): RPS6KA1 (RSK1) (Song et al. 2003), RPS6KA2 (RSK3) (Schinelli et al. 2001), RPS6KA3 (RSK2) (De Cesare et al. 1998, Harum et al. 2001), and probably by RPS6KA6 (RSK4).

Literature References
PubMed ID Title Journal Year
11698596 Stimulation of endothelin B receptors in astrocytes induces cAMP response element-binding protein phosphorylation and c-fos expression via multiple mitogen-activated protein kinase signaling pathways

Gallo, V, Paolillo, M, Zanassi, P, Schinelli, S, Feliciello, A, Wang, H

J. Neurosci. 2001
11160957 Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation

Harum, KH, Johnston, MV, Alemi, L

Neurology 2001
9770464 Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene

Jacquot, S, Hanauer, A, De Cesare, D, Sassone-Corsi, P

Proc Natl Acad Sci U S A 1998
12842905 Induction of MUC8 gene expression by interleukin-1 beta is mediated by a sequential ERK MAPK/RSK1/CREB cascade pathway in human airway epithelial cells

Chung, KC, Cho, KN, Seong, JK, Lee, WJ, Yoon, JH, Song, KS, Koo, JS, Kim, CH, Kang, CD

J. Biol. Chem. 2003
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Catalyst Activity

protein serine/threonine kinase activity of p-S221,T359,S363,S380,T573,T732-RSK [nucleoplasm]

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