Formation of the Flap Intermediate on the C-strand

Stable Identifier
R-HSA-174438
Type
Reaction
Species
Homo sapiens
Compartment
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When the polymerase delta:PCNA complex reaches a downstream Okazaki fragment, strand displacement synthesis occurs. The primer containing 5'-terminus of the downstream Okazaki fragment is folded into a single-stranded flap (Podust et al. 1995, Bae et al. 2001, Maga et al. 2001). The helicase activity of either WRN (Werner syndrome protein) or BLM (Bloom syndrome helicase) is needed for DNA polymerase delta progression and strand displacement synthesis across G-rich telomeric repeats during lagging strand (C-strand) synthesis (Li et al. 2017).

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Event Information
Catalyst Activity

3'-5' DNA helicase activity of BLM,WRN [nucleoplasm]

Orthologous Events
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