Formation of the Flap Intermediate on the C-strand

Stable Identifier
R-HSA-174438
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Formation of the Flap Intermediate on the C-strand
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When the polymerase delta:PCNA complex reaches a downstream Okazaki fragment, strand displacement synthesis occurs. The primer containing 5'-terminus of the downstream Okazaki fragment is folded into a single-stranded flap (Podust et al. 1995, Bae et al. 2001, Maga et al. 2001). The helicase activity of either WRN (Werner syndrome protein) or BLM (Bloom syndrome helicase) is needed for DNA polymerase delta progression and strand displacement synthesis across G-rich telomeric repeats during lagging strand (C-strand) synthesis (Li et al. 2017).
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as an event of
Event Information
Go Biological Process
telomere maintenance via semi-conservative replication (0032201)
Catalyst Activity

3'-5' DNA helicase activity of BLM,WRN [nucleoplasm]

Physical Entity
BLM,WRN [nucleoplasm] (Homo sapiens)
Activity
3'-5' DNA helicase activity (GO:0043138)
Orthologous Events
Formation of the Flap Intermediate on the C-strand (Bos taurus)
Formation of the Flap Intermediate on the C-strand (Canis familiaris)
Formation of the Flap Intermediate on the C-strand (Mus musculus)
Formation of the Flap Intermediate on the C-strand (Rattus norvegicus)
Formation of the Flap Intermediate on the C-strand (Sus scrofa)
Authored
Blackburn, EH  (2006-03-10)
Seidel, J  (2006-03-10)
Reviewed
Hayashi, MT  (2020-04-29)
Price, C  (2006-07-13)
Created
Gillespie, ME  (2006-02-18)
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