Reactome | DNA-PKcs autophosphorylates

DNA-PKcs autophosphorylates

Stable Identifier

R-HSA-5693575

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Autophosphorylation of DNA-PKcs (PRKDC) is required for NHEJ in vivo, especially for endonucleolytic processing of DNA double strand break ends, which makes them suitable for ligation (Chan et al, 2002; Ding et al, 2003). In vivo, PRKDC autophosphorylates at threonine residues T2609, T2638 and T2647, and serine residue S2612 (Douglas et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
12186630	Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. Douglas, P, Sapkota, GP, Morrice, N, Yu, Y, Goodarzi, AA, Merkle, D, Meek, K, Alessi, DR, Lees-Miller, SP	Biochem J	2002
12231622	Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Chan, DW, Chen, BP, Prithivirajsingh, S, Kurimasa, A, Story, MD, Qin, J, Chen, DJ	Genes Dev	2002
12897153	Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. Ding, Q, Reddy, YV, Wang, W, Woods, T, Douglas, P, Ramsden, DA, Lees-Miller, SP, Meek, K	Mol Cell Biol	2003