NLK phosphorylates TCF/LEF

Stable Identifier
R-HSA-4411383
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NLK phosphorylates TCF/LEF
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Activated NLK phosphorylates TCF7L2 and LEF1 at serine and threonine residues that lie in the central region between the DNA-binding and beta-catenin interaction domains. Phosphorylation does not affect the ability of TCF/LEF to bind to beta-catenin, but the phosphorylated complex is not able to bind to target DNA or activate transcription as assessed by EMSA and reporter gene assays (Ishitani et al, 2003b).
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Catalyst Activity

protein serine/threonine kinase activity of pT298-NLK dimer [nucleoplasm]

Physical Entity
pT298-NLK dimer [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
NLK phosphorylates TCF/LEF (Bos taurus)
NLK phosphorylates TCF/LEF (Caenorhabditis elegans)
NLK phosphorylates TCF/LEF (Canis familiaris)
NLK phosphorylates TCF/LEF (Drosophila melanogaster)
NLK phosphorylates TCF/LEF (Gallus gallus)
NLK phosphorylates TCF/LEF (Mus musculus)
NLK phosphorylates TCF/LEF (Rattus norvegicus)
NLK phosphorylates TCF/LEF (Sus scrofa)
Authored
Rothfels, K  (2013-08-24)
Reviewed
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2013-08-24)
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