Activated ATM phosphorylates ABL1

Stable Identifier
R-HSA-5686578
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activated ATM phosphorylates ABL1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ATM, activated in response to DNA damage in the form of double-strand breaks, phosphorylates ABL1 (c-ABL) on serine residue S456, resulting in the activation of kinase activity of ABL1 (Baskaran et al. 1997).
Literature References
PubMed ID Title Journal Year
9168116 Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

Morgan, SE, Kastan, MB, Wynshaw-Boris, A, Wang, JY, Baltimore, D, Barlow, C, Baskaran, R, Canman, CE, Wood, LD, Xu, Y, Whitaker, LL

Nature 1997
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]

Physical Entity
p-S1981,Ac-K3016-ATM [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Activated ATM phosphorylates ABL1 (Bos taurus)
Activated ATM phosphorylates ABL1 (Canis familiaris)
Activated ATM phosphorylates ABL1 (Drosophila melanogaster)
Activated ATM phosphorylates ABL1 (Gallus gallus)
Activated ATM phosphorylates ABL1 (Mus musculus)
Activated ATM phosphorylates ABL1 (Rattus norvegicus)
Activated ATM phosphorylates ABL1 (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-05-12)
Reviewed
Borowiec, JA  (2015-06-12)
Created
Orlic-Milacic, M  (2015-04-02)
Cite Us!