Reactome | Activated ATM phosphorylates ABL1

Activated ATM phosphorylates ABL1

Stable Identifier

R-HSA-5686578

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

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ATM, activated in response to DNA damage in the form of double strand breaks, phosphorylates ABL1 (c-ABL) on serine residue S456, resulting in the activation of kinase activity of ABL1 (Baskaran et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
9168116	Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation Baskaran, R, Wood, LD, Whitaker, LL, Canman, CE, Morgan, SE, Xu, Y, Barlow, C, Baltimore, D, Wynshaw-Boris, A, Kastan, MB, Wang, JY	Nature	1997