Activated ATM phosphorylates ABL1

Stable Identifier
R-HSA-5686578
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ATM, activated in response to DNA damage in the form of double-strand breaks, phosphorylates ABL1 (c-ABL) on serine residue S456, resulting in the activation of kinase activity of ABL1 (Baskaran et al. 1997).

Literature References
PubMed ID Title Journal Year
9168116 Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

Morgan, SE, Kastan, MB, Wynshaw-Boris, A, Wang, JY, Baltimore, D, Barlow, C, Baskaran, R, Canman, CE, Wood, LD, Xu, Y, Whitaker, LL

Nature 1997
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
Cite Us!