Reactome | CHEK1 phosphorylates RAD51

CHEK1 phosphorylates RAD51

Stable Identifier

R-HSA-5685230

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        Homologous DNA Pairing and Strand Exchange (Homo sapiens)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Homo sapiens)
        
        CHEK1 phosphorylates RAD51 (Homo sapiens)

General

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Activated CHEK1 phosphorylates RAD51 on threonine residue T309, which is necessary for RAD51 association with chromatin (Sorensen et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15665856	The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair Lundin, C, Bartek, J, Dziegielewski, J, Helleday, T, Hansen, LT, Sørensen, CS, Syljuåsen, RG	Nat. Cell Biol.	2005