Phosphorylation of MDM4 by CHEK2

Stable Identifier
R-HSA-349426
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylation of MDM4 by CHEK2
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CHEK2 (Chk2) kinase is required for phosphorylation of MDM4 at serine residues S342 and S367 in vivo. CHEK2-mediated phosphorylation stimulates MDM4 ubiquitination by MDM2 and subsequent degradation (Chen et al. 2005).
Literature References
PubMed ID Title Journal Year
16163388 ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

Chen, L, Gilkes, DM, Pan, Y, Lane, WS, Chen, J

EMBO J 2005
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Catalyst Activity

protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm]

Physical Entity
p-S,3T-CHEK2 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of MDM4 by CHEK2 (Canis familiaris)
Phosphorylation of MDM4 by CHEK2 (Gallus gallus)
Phosphorylation of MDM4 by CHEK2 (Mus musculus)
Phosphorylation of MDM4 by CHEK2 (Rattus norvegicus)
Authored
Matthews, L  (2008-03-31)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Matthews, L  (2008-05-08)
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