Reactome | CCNA:CDK1 phosphorylates CDC25B

CCNA:CDK1 phosphorylates CDC25B

Stable Identifier

R-HSA-9929935

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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CCNA2:CDK1 complex was reported to phosphorylate CDC25B in late G2, targeting it for proteasome-mediated degradation, which is an important step for G2/M transition (Baldin et al. 1997). While CCNB1:CDK1 and CCNA2:CDK2 can also phosphorylate CDC25B, the phosphorylated residues likely differ for the three CDK2 complexes, based on differences in migration of phosphorylated CDC25B in denaturing polyacrylamide gels, and only CCNA2:CDK1-mediated phosphorylation leads to proteasomal degradation of CDC25B (Baldin et al. 1997). CDC25B (MPIP2) was also reproducibly identified as a target of the CCNA2:CDK1 complex in a high-throughput study (Dumitru et al. 2017).

Literature References

PubMed ID	Title	Journal	Year
9407044	Phosphorylation of human CDC25B phosphatase by CDK1-cyclin A triggers its proteasome-dependent degradation Baldin, V, Cans, C, Knibiehler, M, Ducommun, B	J Biol Chem	1997
29154753	Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability Dumitru, AMG, Rusin, SF, Clark, AEM, Kettenbach, AN, Compton, DA	Elife	2017