ERK1/2 phosphorylates MSK1

Stable Identifier
R-HSA-198756
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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ERK1/2 phosphorylates MSK1
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MSK1 (Ribosomal protein S6 kinase alpha-5) is a serine/threonine kinase that is localised in the nucleus. It contains two protein kinase domains in a single polypeptide. It can be activated 5-fold by ERK1/2 through phosphorylation at four key residues.
Literature References
PubMed ID Title Journal Year
9687510 Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

Deak, M, Clifton, AD, Lucocq, LM, Alessi, DR

EMBO J 1998
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T,Y MAPK dimers [nucleoplasm]

Physical Entity
p-T,Y MAPK dimers [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
ERK1/2 phosphorylates MSK1 (Bos taurus)
ERK1/2 phosphorylates MSK1 (Caenorhabditis elegans)
ERK1/2 phosphorylates MSK1 (Canis familiaris)
ERK1/2 phosphorylates MSK1 (Dictyostelium discoideum)
ERK1/2 phosphorylates MSK1 (Drosophila melanogaster)
ERK1/2 phosphorylates MSK1 (Gallus gallus)
ERK1/2 phosphorylates MSK1 (Mus musculus)
ERK1/2 phosphorylates MSK1 (Rattus norvegicus)
ERK1/2 phosphorylates MSK1 (Saccharomyces cerevisiae)
ERK1/2 phosphorylates MSK1 (Schizosaccharomyces pombe)
ERK1/2 phosphorylates MSK1 (Sus scrofa)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
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