ERK1/2 phosphorylates MSK1

Stable Identifier
R-HSA-198756
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MSK1 (Ribosomal protein S6 kinase alpha-5) is a serine/threonine kinase that is localised in the nucleus. It contains two protein kinase domains in a single polypeptide. It can be activated 5-fold by ERK1/2 through phosphorylation at four key residues.

Literature References
PubMed ID Title Journal Year
9687510 Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

Deak, M, Clifton, AD, Lucocq, LM, Alessi, DR

EMBO J 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T,Y MAPK dimers [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created