Reactome | MSK1 activates ATF1

MSK1 activates ATF1

Stable Identifier

R-HSA-199910

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-17 signaling (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MSK1 activates ATF1 (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MSK1 activates ATF1 (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MSK1 activates ATF1 (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MSK1 activates ATF1 (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MSK1 activates ATF1 (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MSK1 activates ATF1 (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MSK1 activates ATF1 (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MSK1 activates ATF1 (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MSK1 activates ATF1 (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MSK1 activates ATF1 (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MSK1 activates ATF1 (Homo sapiens)

General

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Cyclic-AMP-dependent transcription factor 1 (ATF1) can be phosphorylated at Serine 63 by MSK1, thus activating it.

Literature References

PubMed ID	Title	Journal	Year
12414794	ATF1 phosphorylation by the ERK MAPK pathway is required for epidermal growth factor-induced c-jun expression Gupta, P, Prywes, R	J. Biol. Chem.	2002

Participants

Input

Output

Participant Of

hasEvent

CREB phosphorylation

Catalyst Activity

Title

protein serine/threonine kinase activity of p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm]

Physical Entity

p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm]

Activity

protein serine/threonine kinase activity (0004674)

Orthologous Events

MSK1 activates ATF1 (Bos taurus)

MSK1 activates ATF1 (Canis familiaris)

MSK1 activates ATF1 (Danio rerio)

MSK1 activates ATF1 (Drosophila melanogaster)

MSK1 activates ATF1 (Mus musculus)

MSK1 activates ATF1 (Rattus norvegicus)

MSK1 activates ATF1 (Sus scrofa)

MSK1 activates ATF1 (Xenopus tropicalis)

Authored

Nasi, S (2006-10-10)

Annibali, D (2006-10-10)

Reviewed

Greene, LA (2007-11-08)

Created

Jassal, B (2007-07-13)