AKT1 E17K mutant phosphorylates NR4A1 (NUR77)

Stable Identifier
R-HSA-2399988
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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AKT1 E17K mutant phosphorylates NR4A1 (NUR77)
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AKT1 E17K gain-of-function mutant is expected to phosphorylate NR4A1, like the wild-type AKT (Pekarsky et al. 2001), but this has not been experimentally tested.
Literature References
PubMed ID Title Journal Year
11274386 Akt phosphorylates and regulates the orphan nuclear receptor Nur77

Pekarsky, Y, Hallas, C, Palamarchuk, A, Koval, A, Bullrich, F, Hirata, Y, Bichi, R, Letofsky, J, Croce, CM

Proc Natl Acad Sci U S A 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [nucleoplasm]

Physical Entity
p-T308,S473-AKT1 E17K [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Normal reaction
AKT can phosphorylate NR4A1 (NUR77) (Homo sapiens)
Functional status

Gain of function of p-T308,S473-AKT1 E17K [nucleoplasm]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Orlic-Milacic, M  (2012-07-18)
Reviewed
Thorpe, L  (2012-08-13)
Yuzugullu, H  (2012-08-13)
Zhao, JJ  (2012-08-13)
Created
Orlic-Milacic, M  (2012-07-13)
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