AKT1 E17K mutant phosphorylates NR4A1 (NUR77)

Stable Identifier
R-HSA-2399988
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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AKT1 E17K gain-of-function mutant is expected to phosphorylate NR4A1, like the wild-type AKT (Pekarsky et al. 2001), but this has not been experimentally tested.

Literature References
PubMed ID Title Journal Year
11274386 Akt phosphorylates and regulates the orphan nuclear receptor Nur77

Pekarsky, Y, Hallas, C, Palamarchuk, A, Koval, A, Bullrich, F, Hirata, Y, Bichi, R, Letofsky, J, Croce, CM

Proc Natl Acad Sci U S A 2001
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [nucleoplasm]

Normal reaction
Functional status

Gain of function of p-T308,S473-AKT1 E17K [nucleoplasm]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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