Reactome | ATM phosphorylates ZNF420

ATM phosphorylates ZNF420

Stable Identifier

R-HSA-6799097

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
        
        ATM phosphorylates ZNF420 (Homo sapiens)

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Activated ATM phosphorylates ZNF420 (Apak) at serine residue S68. Phosphorylation at S68 inhibits ZNF420 binding to the first intron of TP53AIP1 (p53AIP1) gene, thus facilitating TP53 (p53)-mediated expression of TP53AIP1 (Yuan et al. 2012). ATM-mediated phosphorylation of ZNF420 also inhibits ZNF420 interaction with TP53 and the consequent TP53 deacetylation (Tian et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19377469	KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis Tian, C, Xing, G, Xie, P, Lu, K, Nie, J, Wang, J, Li, L, Gao, M, Zhang, L, He, F	Nat. Cell Biol.	2009
22334068	Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis Yuan, L, Tian, C, Wang, H, Song, S, Li, D, Xing, G, Yin, Y, He, F, Zhang, L	EMBO Rep.	2012