ATM phosphorylates ZNF420

Stable Identifier
R-HSA-6799097
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated ATM phosphorylates ZNF420 (Apak) at serine residue S68. Phosphorylation at S68 inhibits ZNF420 binding to the first intron of TP53AIP1 (p53AIP1) gene, thus facilitating TP53 (p53)-mediated expression of TP53AIP1 (Yuan et al. 2012). ATM-mediated phosphorylation of ZNF420 also inhibits ZNF420 interaction with TP53 and the consequent TP53 deacetylation (Tian et al. 2009).

Literature References
PubMed ID Title Journal Year
22334068 Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis

Yuan, L, Tian, C, Wang, H, Song, S, Li, D, Xing, G, Yin, Y, He, F, Zhang, L

EMBO Rep. 2012
19377469 KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis

Tian, C, Xing, G, Xie, P, Lu, K, Nie, J, Wang, J, Li, L, Gao, M, Zhang, L, He, F

Nat. Cell Biol. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created