AKT1 E17K mutant phosphorylates RSK

Stable Identifier
R-HSA-2399999
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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AKT1 E17K gain-of-function mutant is expected to phosphorylate ribosomal protein S6 kinase beta-2, like the wild-type AKT (Koh et al. 1999), but this has not been experimentally tested.

Literature References
PubMed ID Title Journal Year
10490848 Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); a novel nuclear target of Akt

Koh, H, Jee, K, Lee, B, Kim, J, Kim, D, Yun, YH, Kim, JW, Choi, HS, Chung, J

Oncogene 1999
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [nucleoplasm]

Normal reaction
Functional status

Gain of function of p-T308,S473-AKT1 E17K [nucleoplasm]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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