DYRK2 phosphorylates TP53

Stable Identifier
R-HSA-6798374
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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DYRK2 phosphorylates TP53
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DYRK2 phosphorylates TP53 at serine residue S46 (Taira et al. 2007).

Literature References
PubMed ID Title Journal Year
17349958 DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage

Taira, N, Nihira, K, Yamaguchi, T, Miki, Y, Yoshida, K

Mol. Cell 2007
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T106,S442-DYRK2 [nucleoplasm]
Physical Entity
p-T106,S442-DYRK2 [nucleoplasm]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
DYRK2 phosphorylates TP53 (Bos taurus)
DYRK2 phosphorylates TP53 (Danio rerio)
DYRK2 phosphorylates TP53 (Drosophila melanogaster)
DYRK2 phosphorylates TP53 (Mus musculus)
DYRK2 phosphorylates TP53 (Rattus norvegicus)
DYRK2 phosphorylates TP53 (Sus scrofa)
DYRK2 phosphorylates TP53 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-09-19)