DYRK2 phosphorylates TP53

Stable Identifier
R-HSA-6798374
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

DYRK2 phosphorylates TP53 at serine residue S46 (Taira et al. 2007).

Literature References
PubMed ID Title Journal Year
17349958 DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage

Miki, Y, Nihira, K, Taira, N, Yoshida, K, Yamaguchi, T

Mol. Cell 2007
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-T106,S442-DYRK2 [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
Cite Us!