Reactome | DYRK2 phosphorylates TP53

DYRK2 phosphorylates TP53

Stable Identifier

R-HSA-6798374

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        DYRK2 phosphorylates TP53 (Homo sapiens)

General

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DYRK2 phosphorylates TP53 at serine residue S46 (Taira et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17349958	DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage Taira, N, Nihira, K, Yamaguchi, T, Miki, Y, Yoshida, K	Mol. Cell	2007