AKT phosphorylates KAT6A

Stable Identifier
R-HSA-6805640
Type
Reaction
Species
Homo sapiens
Compartment
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Activated AKT phosphorylates the histone acetyltransferase KAT6A on threonine residue T369, preventing association of PML with the KAT6A complex and repressing KAT6A-mediated acetylation of TP53 (p53) (Rokudai et al. 2013).

Literature References
PubMed ID Title Journal Year
23431171 MOZ increases p53 acetylation and premature senescence through its complex formation with PML

Taya, Y, Rokudai, S, Prives, C, Arnal, SM, Laptenko, O, Kitabayashi, I

Proc. Natl. Acad. Sci. U.S.A. 2013
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]

Orthologous Events
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