NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842

Stable Identifier
R-HSA-6790987
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842
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NAT10 transfers an acetyl group from acetyl coenzyme A to the N4 positions of the residues that will become cytidine 1337 and cytidine-1842 in 18S rRNA (Ito et al. 2014, Sharma et al. 2015). (The point at which NAT10 acts during rRNA nucleolytic processing is unknown.) NAT10 also hydrolyzes ATP, presumably to provide helicase activity for the reaction (Ito et al. 2014, Sharma et al. 2015). NAT10 in a complex with THUMPD1 also acetylates tRNAs, however THUMPD1 is not required for acetylation of rRNA (Sharma et al. 2015).
Literature References
PubMed ID Title Journal Year
25411247 Human NAT10 is an ATP-dependent RNA acetyltransferase responsible for N4-acetylcytidine formation in 18 S ribosomal RNA (rRNA)

Ito, S, Horikawa, S, Suzuki, T, Kawauchi, H, Tanaka, Y, Suzuki, T, Suzuki, T

J. Biol. Chem. 2014
25653167 Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1

Sharma, S, Langhendries, JL, Watzinger, P, Kötter, P, Entian, KD, Lafontaine, DL

Nucleic Acids Res. 2015
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Catalyst Activity

N-acetyltransferase activity of NAT10:THUMPD1 [nucleoplasm]

Physical Entity
NAT10:THUMPD1 [nucleoplasm] (Homo sapiens)
Activity
N-acetyltransferase activity (GO:0008080)
Authored
May, B  (2015-08-15)
Reviewed
Vincent, NG  (2016-01-30)
Sharma, S  (2016-02-12)
Created
May, B  (2015-08-16)
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