CDK1 phosphorylates RUNX2

Stable Identifier
R-HSA-9009282
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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CDK1 phosphorylates RUNX2
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RUNX2, presumably in complex with CBFB, can be phosphorylated by the complex of CDK1 and cyclin B. The interaction was demonstrated between endogenous human RUNX2 and CDK1:CCNB1. It was also shown in human cells that RUNX2 undergoes CDK1:CCNB1-mediated phosphorylation on serine residue S451 of RUNX2-P2 isoform. This residue corresponds to the mouse Runx-P1 serine residue S472 (Qiao et al. 2006, Rajgopal et al. 2007). At mitotic exit, RUNX2 is dephosphorylated by unidentified PP1 or PP2A phosphatase (Rajgopal et al. 2007).

Literature References
PubMed ID Title Journal Year
17171635 Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cells

Rajgopal, A, Young, DW, Mujeeb, KA, Stein, JL, Lian, JB, van Wijnen, AJ, Stein, GS

J. Cell. Biochem. 2007
16407259 Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation

Qiao, M, Shapiro, P, Fosbrink, M, Rus, H, Kumar, R, Passaniti, A

J. Biol. Chem. 2006
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase activity of CCNB1:p-T161-CDK1 [nucleoplasm]
Physical Entity
CCNB1:p-T161-CDK1 [nucleoplasm]
Activity
cyclin-dependent protein serine/threonine kinase activity (0004693)
Orthologous Events
CDK1 phosphorylates RUNX2 (Bos taurus)
CDK1 phosphorylates RUNX2 (Caenorhabditis elegans)
CDK1 phosphorylates RUNX2 (Canis familiaris)
CDK1 phosphorylates RUNX2 (Danio rerio)
CDK1 phosphorylates RUNX2 (Drosophila melanogaster)
CDK1 phosphorylates RUNX2 (Mus musculus)
CDK1 phosphorylates RUNX2 (Rattus norvegicus)
CDK1 phosphorylates RUNX2 (Sus scrofa)
CDK1 phosphorylates RUNX2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2017-06-16)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-16)