CDK1 phosphorylates RUNX2

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RUNX2, presumably in complex with CBFB, can be phosphorylated by the complex of CDK1 and cyclin B. The interaction was demonstrated between endogenous human RUNX2 and CDK1:CCNB1. It was also shown in human cells that RUNX2 undergoes CDK1:CCNB1-mediated phosphorylation on serine residue S451 of RUNX2-P2 isoform. This residue corresponds to the mouse Runx-P1 serine residue S472 (Qiao et al. 2006, Rajgopal et al. 2007). At mitotic exit, RUNX2 is dephosphorylated by unidentified PP1 or PP2A phosphatase (Rajgopal et al. 2007).

Literature References
PubMed ID Title Journal Year
17171635 Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cells

Rajgopal, A, Young, DW, Mujeeb, KA, Stein, JL, Lian, JB, van Wijnen, AJ, Stein, GS

J. Cell. Biochem. 2007
16407259 Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation

Qiao, M, Shapiro, P, Fosbrink, M, Rus, H, Kumar, R, Passaniti, A

J. Biol. Chem. 2006
Participant Of
Catalyst Activity
Catalyst Activity
cyclin-dependent protein serine/threonine kinase activity of CCNB1:p-T161-CDK1 [nucleoplasm]
Physical Entity
Orthologous Events
Cite Us!