Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex

Stable Identifier
Reaction [transition]
Homo sapiens
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In late G1, cyclin D dependent kinases CDK4 and CDK6 phosphorylate RBL1 (p107) on four serine and threonine residues (S964, S975, T369 and S640), leading to dissociation of phosphorylated RBL1 (p107) from E2F4 in complex with either DP-1 or DP-2. E2F4, which lacks nuclear localization signal, is then thought to translocate to the cytosol, allowing E2F promoter sites to become occupied by activating E2Fs (E2F1, E2F2, and E2F3), resulting in transcription of E2F targets needed for cell cycle progression.

Literature References
PubMed ID Title Journal Year
7797074 Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes

Kerkhoven, RM, Carlée, L, Beijersbergen, RL, Bernards, R

Genes Dev 1995
9144196 The subcellular localization of E2F-4 is cell-cycle dependent

Livingston, DM, Gaubatz, S, Lindeman, GJ, Ginsberg, D

Proc Natl Acad Sci U S A 1997
11884610 Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4

Leng, X, Adams, PD, Noble, M, Qin, J, Harper, JW

Mol Cell Biol 2002
Catalyst Activity

cyclin-dependent protein serine/threonine kinase activity of p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm]

Orthologous Events
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