Reactome | ATR phosphorylates TP53

ATR phosphorylates TP53

Stable Identifier

R-HSA-6799332

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        ATR phosphorylates TP53 (Homo sapiens)

General

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ATR, bound to DNA damage sites, phosphorylates TP53 (p53) at serine residue S15. S15 phosphorylation stabilizes TP53 by inhibiting the binding of TP53 to the ubiquitin ligase MDM2 (Tibbetts et al. 1999, Lakin et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10435622	The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53 Jackson, SP, Hann, BC, Lakin, ND	Oncogene	1999
9925639	A role for ATR in the DNA damage-induced phosphorylation of p53 Tibbetts, RS, Abraham, RT, Williams, JM, Sarkaria, JN, Brumbaugh, KM, Cliby, WA, Taya, Y, Prives, C, Shieh, SY	Genes Dev.	1999

Participants

Input

Output

Participates

as an event of

Catalyst Activity

protein serine/threonine kinase activity of ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]

Physical Entity

ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)

Activity

protein serine/threonine kinase activity (GO:0004674)

Orthologous Events

ATR phosphorylates TP53 (Bos taurus)

ATR phosphorylates TP53 (Canis familiaris)

ATR phosphorylates TP53 (Drosophila melanogaster)

ATR phosphorylates TP53 (Mus musculus)

ATR phosphorylates TP53 (Rattus norvegicus)

ATR phosphorylates TP53 (Sus scrofa)

ATR phosphorylates TP53 (Xenopus tropicalis)