ATR phosphorylates TP53

Stable Identifier
R-HSA-6799332
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ATR, bound to DNA damage sites, phosphorylates TP53 (p53) at serine residue S15. S15 phosphorylation stabilizes TP53 by inhibiting the binding of TP53 to the ubiquitin ligase MDM2 (Tibbetts et al. 1999, Lakin et al. 1999).

Literature References
PubMed ID Title Journal Year
10435622 The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53

Jackson, SP, Hann, BC, Lakin, ND

Oncogene 1999
9925639 A role for ATR in the DNA damage-induced phosphorylation of p53

Tibbetts, RS, Abraham, RT, Williams, JM, Sarkaria, JN, Brumbaugh, KM, Cliby, WA, Taya, Y, Prives, C, Shieh, SY

Genes Dev. 1999
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm]

Orthologous Events
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