MECP2 is phosphorylated at S423

Stable Identifier
R-HSA-9006992
Type
Reaction [transition]
Species
Homo sapiens
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In resting neurons, MECP2 is phosphorylated at serine residue S80, which results in a decreased association of MECP2 with chromatin. In activity-induced neurons, upon neuronal membrane depolarization, MECP2 S80 becomes dephosphorylated, and MECP2 acquires phosphorylation on serine S423 (corresponding to mouse Mecp2 serine S421). CaMK IV is one of the kinases that can phosphorylate MECP2 on S423. Phosphorylation of MECP2 at S423 increases MECP2 binding to chromatin (Zhou et al. 2006, Tao et al. 2009, Qiu et al. 2012).

Literature References
PubMed ID Title Journal Year
17046689 Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation

Zhou, Z, Hong, EJ, Cohen, S, Zhao, WN, Ho, HY, Schmidt, L, Chen, WG, Lin, Y, Savner, E, Griffith, EC, Hu, L, Steen, JA, Weitz, CJ, Greenberg, ME

Neuron 2006
19225110 Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function

Tao, J, Hu, K, Chang, Q, Wu, H, Sherman, NE, Martinowich, K, Klose, RJ, Schanen, C, Jaenisch, R, Wang, W, Sun, YE

Proc. Natl. Acad. Sci. U.S.A. 2009
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Catalyst Activity
Title
calmodulin-dependent protein kinase activity of Active CaMK IV,(CaMK II) [nucleoplasm]
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