MECP2 is phosphorylated at S423

Stable Identifier
R-HSA-9006992
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MECP2 is phosphorylated at S423
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In resting neurons, MECP2 is phosphorylated at serine residue S80, which results in a decreased association of MECP2 with chromatin. In activity-induced neurons, upon neuronal membrane depolarization, MECP2 S80 becomes dephosphorylated, and MECP2 acquires phosphorylation on serine S423 (corresponding to mouse Mecp2 serine S421). CaMK IV is one of the kinases that can phosphorylate MECP2 on S423. Phosphorylation of MECP2 at S423 increases MECP2 binding to chromatin (Zhou et al. 2006, Tao et al. 2009, Qiu et al. 2012).
Literature References
PubMed ID Title Journal Year
19225110 Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function

Sun, YE, Klose, RJ, Wu, H, Jaenisch, R, Tao, J, Sherman, NE, Martinowich, K, Schanen, C, Wang, W, Chang, Q, Hu, K

Proc. Natl. Acad. Sci. U.S.A. 2009
17046689 Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation

Greenberg, ME, Griffith, EC, Ho, HY, Steen, JA, Lin, Y, Hu, L, Chen, WG, Zhao, WN, Cohen, S, Hong, EJ, Savner, E, Schmidt, L, Weitz, CJ, Zhou, Z

Neuron 2006
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Input
Output
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as an event of
Catalyst Activity

calcium/calmodulin-dependent protein kinase activity of Active CaMK IV,(CaMK II) [nucleoplasm]

Physical Entity
Active CaMK IV,(CaMK II) [nucleoplasm] (Homo sapiens)
Activity
calcium/calmodulin-dependent protein kinase activity (GO:0004683)
Inferred From
Mecp2 is phosphorylated at S421 (Mus musculus)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-05-25)
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