Recombinant mouse Runx2-P1 isoform is phosphorylated by recombinant activated ERK1 (MAPK3) on conserved serine residues S301 and S319 (Ge et al. 2009), which correspond to serine residues S286 and S304 in Runx2-P2 isoform. The species of the recombinant commercial ERK1 used in the mouse study was not specified and it is assumed to be human derived.
Ge, C, Xiao, G, Jiang, D, Yang, Q, Hatch, NE, Roca, H, Franceschi, RT
protein serine/threonine kinase activity of p-Y185,Y187 MAPK1 dimer [nucleoplasm]
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