Activated ERKs phosphorylate Runx2

Stable Identifier
R-NUL-9009236
Type
Reaction [transition]
Species
Homo sapiens
Compartment
General
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Activated ERKs phosphorylate Runx2

Recombinant mouse Runx2-P1 isoform is phosphorylated by recombinant activated ERK1 (MAPK3) on conserved serine residues S301 and S319 (Ge et al. 2009), which correspond to serine residues S286 and S304 in Runx2-P2 isoform. The species of the recombinant commercial ERK1 used in the mouse study was not specified and it is assumed to be human derived.

Literature References
PubMed ID Title Journal Year
19801668 Identification and functional characterization of ERK/MAPK phosphorylation sites in the Runx2 transcription factor

Ge, C, Xiao, G, Jiang, D, Yang, Q, Hatch, NE, Roca, H, Franceschi, RT

J. Biol. Chem. 2009
Participants
Catalyst Activity

protein serine/threonine kinase activity of p-Y185,Y187 MAPK1 dimer [nucleoplasm]

Orthologous Events
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