Reactome | PLK3 phosphorylates TP53

PLK3 phosphorylates TP53

Stable Identifier

R-HSA-6805285

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        PLK3 phosphorylates TP53 (Homo sapiens)

General

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PLK3 contributes to stabilizing phosphorylation of TP53 on serine residue S20 (Xie, Wang et al. 2001, Xie, Wu et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11551930	Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway Xie, S, Wu, H, Wang, Q, Cogswell, JP, Husain, I, Conn, C, Stambrook, P, Jhanwar-Uniyal, M, Dai, W	J. Biol. Chem.	2001
11447225	Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3 Xie, S, Wang, Q, Wu, H, Cogswell, J, Lu, L, Jhanwar-Uniyal, M, Dai, W	J. Biol. Chem.	2001