PLK3 phosphorylates TP53

Stable Identifier
R-HSA-6805285
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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PLK3 contributes to stabilizing phosphorylation of TP53 on serine residue S20 (Xie, Wang et al. 2001, Xie, Wu et al. 2001).
Literature References
PubMed ID Title Journal Year
11551930 Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway

Husain, I, Wang, Q, Stambrook, P, Dai, W, Wu, H, Xie, S, Conn, C, Cogswell, JP, Jhanwar-Uniyal, M

J. Biol. Chem. 2001
11447225 Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3

Wang, Q, Dai, W, Wu, H, Lu, L, Xie, S, Cogswell, J, Jhanwar-Uniyal, M

J. Biol. Chem. 2001
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of PLK3 [nucleoplasm]

Orthologous Events
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