The interaction between the Skp2 subunit of the SCF(Skp2) complex and p27 is dependent upon Cdk2:Cyclin A/E mediated phosphorylation of p27 at Thr 187 (Carrano et al, 1999; Tsvetkov et al, 1999). There is evidence that Cyclin A/B:Cdk1 can also bind and phosphorylate p27 on Thr 187 (Nakayama et al., 2004). This phosphorylation is also essential for the subsequent ubiquitination of p27.
Eytan, E, Hershko, A, Pagano, M, Carrano, AC
Eytan, E, Draetta, GF, Hershko, A, Montagnoli, A, Pagano, M, Carrano, AC, Fiore, F
Sun, H, Zhang, H, Tsvetkov, LM, Lee, SJ, Yeh, KH
cyclin-dependent protein serine/threonine kinase activity of Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm]
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