Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21

Stable Identifier
Homo sapiens
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The interaction between the Skp2 subunit of the SCF(Skp2) complex and p27 is dependent upon Cdk2:Cyclin A/E mediated phosphorylation of p27 at Thr 187 (Carrano et al, 1999; Tsvetkov et al, 1999). There is evidence that Cyclin A/B:Cdk1 can also bind and phosphorylate p27 on Thr 187 (Nakayama et al., 2004). This phosphorylation is also essential for the subsequent ubiquitination of p27.

Literature References
PubMed ID Title Journal Year
10559916 SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

Eytan, E, Hershko, A, Pagano, M, Carrano, AC

Nat Cell Biol 1999
10323868 Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

Eytan, E, Draetta, GF, Hershko, A, Montagnoli, A, Pagano, M, Carrano, AC, Fiore, F

Genes Dev 1999
10375532 p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

Sun, H, Zhang, H, Tsvetkov, LM, Lee, SJ, Yeh, KH

Curr Biol 1999
Catalyst Activity

cyclin-dependent protein serine/threonine kinase activity of Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm]

Orthologous Events
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