activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3

Stable Identifier
R-GGA-438019
Type
Reaction [transition]
Species
Gallus gallus
Compartment
nucleoplasm
ReviewStatus
5/5
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activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The MAPK level components of this cascade are p38MAPK-alpha, -beta, -gamma and -sigma. All of those isoforms are activated by phosphorylation of the Thr and Tyr in the Thr-Gly-Tyr motif in their activation loops.
Literature References
PubMed ID Title Journal Year
8622669 MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

Davis, RJ, Whitmarsh, AJ, Derijard, B, Raingeaud, J, Barrett, T

Mol Cell Biol 1996
7535770 Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

Gupta, S, Davis, RJ, Ulevitch, RJ, Han, J, Raingeaud, J, Dickens, M, Rogers, JS

J Biol Chem 1995
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Catalyst Activity

protein serine/threonine/tyrosine kinase activity of phospho MKK3/ phospho MKK6 [nucleoplasm]

Physical Entity
phospho MKK3/ phospho MKK6 [nucleoplasm] (Gallus gallus)
Activity
protein serine/threonine/tyrosine kinase activity (GO:0004712)
Inferred From
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
Authored
Shamovsky, V  (2009-09-22)
Reviewed
D'Eustachio, P  (2010-05-23)
Created
Shamovsky, V  (2009-09-22)
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