MAP2K6 phosphorylates PIP4K2B

Stable Identifier
R-HSA-8877691
Type
Reaction
Species
Homo sapiens
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Under conditions of cellular stress, such as increased level of reactive oxygen species, MAP2K6 (MKK6), and possibly other kinases of the p38 MAPK family, phosphorylates PIP4K2B at serine residue S326. Threonine residue T322 of PIP4K2B is also phosphorylated under stress conditions, but the responsible kinase is not known. MAP2K6 may also phosphorylate PIP4K2A, but not PIP4K2C (Kuene et al. 2012).

Literature References
PubMed ID Title Journal Year
23193159 Regulation of phosphatidylinositol-5-phosphate signaling by Pin1 determines sensitivity to oxidative stress

Zhou, XZ, Sommer, L, Lu, KP, Jones, DR, Bultsma, Y, Keune, WJ, Divecha, N

Sci Signal 2012
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Catalyst Activity

protein serine/threonine kinase activity of p-S207,T211-MAP2K6 [nucleoplasm]

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