Reactome | MAP2K6 phosphorylates PIP4K2B

MAP2K6 phosphorylates PIP4K2B

Stable Identifier

R-HSA-8877691

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Acetylation (Homo sapiens)
        
        PI5P Regulates TP53 Acetylation (Homo sapiens)
        
        MAP2K6 phosphorylates PIP4K2B (Homo sapiens)

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Under conditions of cellular stress, such as increased level of reactive oxygen species, MAP2K6 (MKK6), and possibly other kinases of the p38 MAPK family, phosphorylates PIP4K2B at serine residue S326. Threonine residue T322 of PIP4K2B is also phosphorylated under stress conditions, but the responsible kinase is not known. MAP2K6 may also phosphorylate PIP4K2A, but not PIP4K2C (Kuene et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
23193159	Regulation of phosphatidylinositol-5-phosphate signaling by Pin1 determines sensitivity to oxidative stress Keune, WJ, Jones, DR, Bultsma, Y, Sommer, L, Zhou, XZ, Lu, KP, Divecha, N	Sci Signal	2012