Cdc6 protein is phosphorylated by CDK

Stable Identifier
R-HSA-69005
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Cdc6 protein is phosphorylated by CDK
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the beginning of this reaction, 1 molecule of 'CDC6', and 1 molecule of 'ATP' are present. At the end of this reaction, 1 molecule of 'ADP', and 1 molecule of 'phosphorylated Cdc6' are present.

This reaction takes place in the 'nucleus' and is mediated by the 'kinase activity' of 'CDK'.

Literature References
PubMed ID Title Journal Year
10339564 Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6.

Jiang, W, Wells, NJ, Hunter, T

Proc Natl Acad Sci U S A 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cyclin-dependent protein serine/threonine kinase activity of CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm]

Physical Entity
CCNA:p-T160-CDK2,CCNE:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
Activity
cyclin-dependent protein serine/threonine kinase activity (GO:0004693)
Orthologous Events
Cdc6 protein is phosphorylated by CDK (Bos taurus)
Cdc6 protein is phosphorylated by CDK (Caenorhabditis elegans)
Cdc6 protein is phosphorylated by CDK (Canis familiaris)
Cdc6 protein is phosphorylated by CDK (Danio rerio)
Cdc6 protein is phosphorylated by CDK (Dictyostelium discoideum)
Cdc6 protein is phosphorylated by CDK (Drosophila melanogaster)
Cdc6 protein is phosphorylated by CDK (Gallus gallus)
Cdc6 protein is phosphorylated by CDK (Mus musculus)
Cdc6 protein is phosphorylated by CDK (Rattus norvegicus)
Cdc6 protein is phosphorylated by CDK (Saccharomyces cerevisiae)
Cdc6 protein is phosphorylated by CDK (Schizosaccharomyces pombe)
Cdc6 protein is phosphorylated by CDK (Sus scrofa)
Cdc6 protein is phosphorylated by CDK (Xenopus tropicalis)
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