p38 MAPK phosphorylates PPARGC1A

Stable Identifier
R-HSA-1592233
Type
Reaction [transition]
Species
Homo sapiens
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As inferred from mouse, p38 MAPK phosphorylates PGC-1alpha (PPARGC1A). Because p38 MAPK is responsive to intracellular calcium, this reaction may couple exercise to mitochondrial biogenesis.
Phosphorylated p38 MAPK is found in the nucleus (Chan et al. 2004, http://www.cellsignal.com/products/4511.html, inferred from mouse in Blanco-Aparicio et al. 1999). p38 MAPK alpha, beta, and gamma (but not delta) are found in skeletal muscle (Jiang et al. 1997). PPARGC1A (PGC-1alpha) is predominantly nuclear (Knutti et al. 2001). As inferred from rat, PPARGC1A may translocate from the cytosol to the nucleus during activation (Wright et al. 2007).

Literature References
PubMed ID Title Journal Year
21451146 An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1? and activates mitochondrial biogenesis in human skeletal muscle

Little, JP, Safdar, A, Bishop, D, Tarnopolsky, MA, Gibala, MJ

Am J Physiol Regul Integr Comp Physiol 2011
10601328 A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase

Blanco-Aparicio, C, Torres, J, Pulido, R

J Cell Biol 1999
11481440 Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor

Knutti, D, Kressler, D, Kralli, A

Proc Natl Acad Sci U S A 2001
17099248 Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1alpha expression

Wright, DC, Han, DH, Garcia-Roves, PM, Geiger, PC, Jones, TE, Holloszy, JO

J Biol Chem 2007
19112161 Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle

Gibala, MJ, McGee, SL, Garnham, AP, Howlett, KF, Snow, RJ, Hargreaves, M

J Appl Physiol 2009
9374491 Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta

Jiang, Y, Gram, H, Zhao, M, New, L, Gu, J, Feng, L, di Padova, F, Ulevitch, RJ, Han, J

J Biol Chem 1997
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Catalyst Activity
Title
protein serine/threonine kinase activity of phospho-p38 alpha/beta/gamma MAPK [nucleoplasm]
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