Reactome | AURKA phosphorylates TP53

AURKA phosphorylates TP53

Stable Identifier

R-HSA-6805103

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        AURKA phosphorylates TP53 (Homo sapiens)

General

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AURKA (Aurora kinase A) phosphorylates TP53 (p53) on serine residue S315. This leads to destabilization of TP53 by enhancing MDM2 binding (Katayama et al. 2004). Based on Xenopus studies, AURKA-mediated phosphorylation of TP53 occurs in the presence of AURKA activator TPX2 (Pascreau et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19121998	Phosphorylation of p53 is regulated by TPX2-Aurora A in xenopus oocytes Pascreau, G, Lewellyn, AL, Maller, JL, Prigent, C, Eckerdt, F	J. Biol. Chem.	2009
14702041	Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53 Sasai, K, Suzuki, F, Sen, S, Fujii, S, Bondaruk, J, Yuan, ZM, Kawai, H, Arlinghaus, RB, Katayama, H, Czerniak, BA	Nat. Genet.	2004