AURKA phosphorylates TP53

Stable Identifier
R-HSA-6805103
Type
Reaction
Species
Homo sapiens
Compartment
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AURKA (Aurora kinase A) phosphorylates TP53 (p53) on serine residue S315. This leads to destabilization of TP53 by enhancing MDM2 binding (Katayama et al. 2004). Based on Xenopus studies, AURKA-mediated phosphorylation of TP53 occurs in the presence of AURKA activator TPX2 (Pascreau et al. 2009).

Literature References
PubMed ID Title Journal Year
19121998 Phosphorylation of p53 is regulated by TPX2-Aurora A in xenopus oocytes

Pascreau, G, Lewellyn, AL, Maller, JL, Prigent, C, Eckerdt, F

J. Biol. Chem. 2009
14702041 Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53

Sasai, K, Suzuki, F, Sen, S, Fujii, S, Bondaruk, J, Yuan, ZM, Kawai, H, Arlinghaus, RB, Katayama, H, Czerniak, BA

Nat. Genet. 2004
Participants
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Catalyst Activity

protein serine/threonine kinase activity of p-T288-AURKA:TPX2 [nucleoplasm]

Orthologous Events
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