AURKA phosphorylates TP53

Stable Identifier
R-HSA-6805103
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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AURKA (Aurora kinase A) phosphorylates TP53 (p53) on serine residue S315. This leads to destabilization of TP53 by enhancing MDM2 binding (Katayama et al. 2004). Based on Xenopus studies, AURKA-mediated phosphorylation of TP53 occurs in the presence of AURKA activator TPX2 (Pascreau et al. 2009).

Literature References
PubMed ID Title Journal Year
14702041 Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53

Katayama, H, Sasai, K, Kawai, H, Yuan, ZM, Bondaruk, J, Suzuki, F, Fujii, S, Arlinghaus, RB, Czerniak, BA, Sen, S

Nat. Genet. 2004
19121998 Phosphorylation of p53 is regulated by TPX2-Aurora A in xenopus oocytes

Pascreau, G, Eckerdt, F, Lewellyn, AL, Prigent, C, Maller, JL

J. Biol. Chem. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T288-AURKA:TPX2 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created