Down Regulation of Emi1 through Phosphorylation of Emi1

Stable Identifier
R-HSA-163010
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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During the early stages of mitosis, Cdc2 and PLK1 cooperate to phosphorylate Emi1 and this modification induces Emi1 degradation through a Skp1-Cullin1 F-box protein (SCF) ubiquitin ligase-mediated proteolysis. Degradation of Emi1 permits activation of anaphase promoting complex and thereby the onset of anaphase.

Literature References
PubMed ID Title Journal Year
15148369 Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome

Moshe, Y, Boulaire, J, Pagano, M, Hershko, A

Proc Natl Acad Sci U S A 2004
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T210-PLK1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Created