Reactome | IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus

IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus

Stable Identifier

R-HSA-1855207

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus

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In the nucleus, inositol hexakisphosphate kinase 1 (IP6K1) and 2 (IP6K2) phosphorylate inositol 1,2,3,4,5,6-hexakisphosphate (IP6) to inositol 5-diphospho-1,2,3,4,6-pentakisphosphate (5-PP-IP5).

The following lists the above proteins with their corresponding literature references: IP6K1 (Saiardi et al. 2001, Mulugu et al. 2007, Draskovic et al. 2008) and IP6K2 (Saiardi et al. 2001, Mulugu et al. 2007, Draskovic et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18355727	Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups Draskovic, P, Saiardi, A, Bhandari, R, Burton, A, Ilc, G, Kovacevic, M, Snyder, SH, Podobnik, M	Chem Biol	2008
11502751	Identification and characterization of a novel inositol hexakisphosphate kinase Saiardi, A, Nagata, E, Luo, HR, Snowman, AM, Snyder, SH	J Biol Chem	2001
17412958	A conserved family of enzymes that phosphorylate inositol hexakisphosphate Mulugu, S, Bai, W, Fridy, PC, Bastidas, RJ, Otto, JC, Dollins, DE, Haystead, TA, Ribeiro, AA, York, JD	Science	2007