Reactome | PLK3 phosphorylates CDC25C

PLK3 phosphorylates CDC25C

Stable Identifier

R-HSA-6802973

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
        
        PLK3 phosphorylates CDC25C (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PLK3 phosphorylates CDC25C at serine residue S191 within the nuclear export signal (NES). Phosphorylation of CDC25C at S191 promotes nuclear localization of CDC25C, probably by masking the NES. Nuclear accumulation of CDC25C may be important for coordination of M phase events (Bahassi et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
14968113	Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation Myer, DL, Bahassi, el M, Stambrook, PJ, Hennigan, RF	Oncogene	2004