Reactome | CHD6-9-dependent ATP hydrolysis

CHD6-9-dependent ATP hydrolysis

Stable Identifier

R-HSA-9944087

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

3/5

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CHD6, CHD7, CHD8 and CHD9 use the energy of ATP hydrolysis to reposition or slide nucleosomes to alter the accessibility of chromatin (Shur et al, 2005; Thompson et al, 2008; Manning and Yusufzai, 2017; reviewed in Alendar and Berns, 2021; Clapier et al, 2017). In vitro biochemical analysis of purified CHD6, CHD7 and CHD8 shows distinct activities for these proteins, with CHD8 binding preferentially to substrates with longer linker DNA than either CHD6 or CHD7 (Manning and Yusufzai, 2017). In the same study (which did not examine CHD9 due to low protein yield), CHD6 exhibited a pattern of nucleosome position disruption that was distinct from the more classical nucleosome sliding shown by CHD7 and CHD8 (Manning and Yusufzai, 2017).

Literature References

PubMed ID	Title	Journal	Year
18378692	CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes Thompson, BA, Tremblay, V, Lin, G, Bochar, DA	Mol. Cell. Biol.	2008
16095617	Characterization and functional analysis of CReMM, a novel chromodomain helicase DNA-binding protein Shur, I, Benayahu, D	J Mol Biol	2005
28533432	The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities Manning, BJ, Yusufzai, T	J Biol Chem	2017
34725129	Sentinels of chromatin: chromodomain helicase DNA-binding proteins in development and disease Alendar, A, Berns, A	Genes Dev	2021
28512350	Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes Clapier, CR, Iwasa, J, Cairns, BR, Peterson, CL	Nat Rev Mol Cell Biol	2017